Gainesville, FL – February 26, 2025 – The Brain Injury, Rehabilitation, and Neuroresilience (BRAIN) Center celebrated cutting-edge neuroscience research last night at the University of Florida College of Medicine Celebration of Research by awarding the top three posters in brain injury and neurorehabilitation. These awards highlight the innovative work of UF researchers dedicated to advancing treatments for brain injury, stroke, and neurodegeneration.
The winners were selected based on scientific merit, impact, and innovation, recognizing the best research efforts in brain resilience and recovery.
Award Winners & Research Highlights
First Place: Kelena Klippel et al
Therapeutic Modulation of Neuroinflammation and Cognitive Deficits Following Mild Traumatic Brain Injury: A Multimodal Approach
(Principal Investigator: Dr. Prodip Bose)
This study explores the use of methylphenidate (MPH) in stabilizing metabolic activity and cognitive function after mild traumatic brain injury (mTBI). Using positron emission tomography (PET)/MRI imaging and behavioral assessments, the research team demonstrated that MPH may reduce neuroinflammation and support recovery in a preclinical model. Their findings provide valuable insight into new therapeutic strategies for TBI patients.
Second Place: Rachel Gunraj et al
Pharmacological Inhibition of PFKFB3 in Aged Male and Female Mice Confers Neuroprotection after Ischemic Stroke
(Principal Investigator: Dr. Eduardo Candelario-Jalil)
With stroke remaining a leading cause of disability, this study investigated the role of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) in stroke outcomes. Researchers found that blocking PFKFB3 reduced infarct size and improved recovery in aged male and female mice, suggesting a promising neuroprotective therapy for ischemic stroke. The findings expand potential treatment avenues for stroke patients who lack access to current standard-of-care interventions.
Third Place: Hunter Hutchinson et al
Delayed Adropin Administration Attenuates Acute Neural Injury in Subarachnoid Hemorrhage (SAH)
(Principal Investigator: Dr. Brian Hoh)
This research highlights the potential of adropin, a metabolic peptide, as a novel treatment for early brain injury following subarachnoid hemorrhage (SAH). The study found that delayed administration of adropin reduced microthrombosis and neuronal apoptosis, marking a significant step forward in SAH treatment strategies.
Advancing Brain Health and Neuroresilience
The BRAIN Center remains committed to supporting groundbreaking research that advances treatments for brain injuries and neurological disorders. “These projects reflect the incredible depth of research being conducted at UF in the fields of brain injury, stroke, and neurorehabilitation,” said Dr. Michael Jaffee, founding director of the BRAIN Center. “It’s inspiring to see the next generation of researchers making such a meaningful impact.”
The UF College of Medicine Celebration of Research is an annual event that showcases the university’s most promising scientific discoveries, fostering collaboration across disciplines and driving innovation in neurology, neuroscience, and rehabilitation medicine.
Congratulations to this year’s award winners for their outstanding contributions to the field!